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Ellagic Acid

Ellagic Acid is a naturally occurring plant phenol found in various berries (1.5-2%), pomegranate (up to 90%) as well as other more exotic plants. Numerous studies show Ellagic Acid to be an effective inhibitor of cancer cell growth. Ellagic Acid acts as a scavenger to bind cancer-causing chemicals, making them inactive. Ellagic Acid also inhibits the ability of other chemicals to cause mutations in bacteria; and it prevents binding of carcinogens to DNA and reduces the incidence of cancer in cultured human cells exposed to carcinogens.

IMMUPRO™ contains 500 mg of red raspberry standardized to 40% Ellagic Acid.

Click the links below for further research on Ellagic acid

Narayanan BA, Re GG.
IGF-II down regulation associated cell cycle arrest in colon cancer cells exposed to phenolic antioxidant ellagic acid. Anticancer Res. 2001 Jan-Feb;21(1A):359-64. PMID: 11299762 [PubMed - indexed for MEDLINE]

Xue H, Aziz RM, Sun N, Cassady JM, Kamendulis LM, Xu Y, Stoner GD, Klaunig JE.
Inhibition of cellular transformation by berry extracts. Carcinogenesis. 2001 Feb;22(2):351-6. PMID: 11181460 [PubMed - indexed for MEDLINE]

Lin SS, Hung CF, Ho CC, Liu YH, Ho HC, Chung JG.
Effects of ellagic acid by oral administration on N-acetylation and metabolism of 2-aminofluorene in rat brain tissues. Neurochem Res. 2000 Nov;25(11):1503-8. PMID: 11071370 [PubMed - indexed for MEDLINE]

Shepherd AG, Manson MM, Ball HW, McLellan LI.
Regulation of rat glutamate-cysteine ligase (gamma-glutamylcysteine synthetase) subunits by chemopreventive agents and in aflatoxin B(1)-induced preneoplasia. Carcinogenesis. 2000 Oct;21(10):1827-34. PMID: 11023540 [PubMed - indexed for MEDLINE]

Khanduja KL, Gandhi RK, Pathania V, Syal N.
Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. Food Chem Toxicol. 1999 Apr;37(4):313-8. PMID: 10418948 [PubMed - indexed for MEDLINE]

Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW.
p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999 Mar 1;136(2):215-21. PMID: 10355751 [PubMed - indexed for MEDLINE]

Singh K, Khanna AK, Chander R.
Hepatoprotective activity of ellagic acid against carbon tetrachloride induced hepatotoxicity in rats. Indian J Exp Biol. 1999 Oct;37(10):1025-6. PMID: 10783760 [PubMed - indexed for MEDLINE]

Singh K, Khanna AK, Visen PK, Chander R.
Protective effect of ellagic acid on t-butyl hydroperoxide induced lipid peroxidation in isolated rat hepatocytes. Indian J Exp Biol. 1999 Sep;37(9):939-40. PMID: 10687292 [PubMed - indexed for MEDLINE]

Ahmed S, Rahman A, Saleem M, Athar M, Sultana S.
Ellagic acid ameliorates nickel induced biochemical alterations: diminution of oxidative stress. Hum Exp Toxicol. 1999 Nov;18(11):691-8. PMID: 10602394 [PubMed - indexed for MEDLINE]

Narayanan BA, Geoffroy O, Willingham MC, Re GG, Nixon DW.
p53/p21(WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett. 1999 Mar 1;136(2):215-21. PMID: 10355751 [PubMed - indexed for MEDLINE]

Chung JG.
Inhibitory actions of ellagic acid on growth and arylamine N-acetyltransferase activity in strains of Helicobacter pylori from peptic ulcer patients. Microbios. 1998;93(375):115-27. PMID: 9697340 [PubMed - indexed for MEDLINE]

Iakovleva LV, Ivakhnenko AK, Buniatian ND.
[The protective action of ellagic acid in experimental myocarditis]. Eksp Klin Farmakol. 1998 May-Jun;61(3):32-4. Russian. PMID: 9690073 [PubMed - indexed for MEDLINE]

 

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