Sulforaphane,4-Methylsulphinylbutyl
isothiocyanate
Sulforaphane is a naturally occurring sulfur-containing isothiocyanate derivative that
helps mobilize the human body's natural cancer-fighting resources and reduces the risk of
developing cancer. Within hours of being ingested, sulforaphane enters the bloodstream
where it circulates widely to trigger the immune system response to carcinogens. The
phytochemical acts by inducing a series of proteins termed phase 2 detoxification enzymes,
which act as scavengers for cancer-causing molecules before they can damage DNA and
promote cancer.
AP Washington release 9/16/97:
"Broccoli Sprouts are loaded with a concentrated form of sulforaphanes, a powerful
cancer fighter", say researchers at Johns Hopkins University. "Studies have
shown that eating 2 pounds of broccoli a week - an unappetizing thought to many people -
can provide enough sulforaphanes to lower colon cancer risk by half. Earlier studies
showed that sulforaphanes, found in broccoli, cauliflower and some other vegetables,
prompts the body to make an enzyme that prevents tumors from forming. A 1994 study
indicated that cancer development was reduced by 60 percent to 80 percent in laboratory
animals fed sulforaphanes extracted from broccoli."
IMMUPRO™ contains 300 mg of 4000 ppm sulforophane standardized
extract per serving.
Click the links below for further research on sulforaphanes
Gamet-Payrastre
L, Li P, Lumeau S, Cassar G, Dupont MA, Chevolleau S, Gasc N, Tulliez J, Terce F.
Sulforaphane, a naturally occurring isothiocyanate, induces cell cycle arrest and
apoptosis in HT29 human colon cancer cells. Cancer Res. 2000 Mar 1;60(5):1426-33. PMID:
10728709 [PubMed - indexed for MEDLINE]
Fahey
JW, Zhang Y, Talalay P.
Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against
chemical carcinogens. Proc Natl Acad Sci U S A. 1997 Sep 16;94(19):10367-72. PMID: 9294217
[PubMed - indexed for MEDLINE]
Zhang
Y, Kensler TW, Cho CG, Posner GH, Talalay P.
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl
isothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50. PMID: 8159717
[PubMed - indexed for MEDLINE]
Fahey
JW, Talalay P.
Antioxidant functions of sulforaphane: a potent inducer of Phase II detoxication enzymes.
Food Chem Toxicol. 1999 Sep-Oct;37(9-10):973-9. Review. No abstract available. PMID:
10541453 [PubMed - indexed for MEDLINE]
Lee
SK, Song L, Mata-Greenwood E, Kelloff GJ, Steele VE, Pezzuto JM.
Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents.
Anticancer Res. 1999 Jan-Feb;19(1A):35-44. PMID: 10226522 [PubMed - indexed for MEDLINE]
Nestle
M.
Broccoli sprouts in cancer prevention. Nutr Rev. 1998 Apr;56(4 Pt 1):127-30. Review. PMID:
9584498 [PubMed - indexed for MEDLINE]
van
Lieshout EM, Posner GH, Woodard BT, Peters WH.
Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen
on glutathione S-transferases and glutathione peroxidase of the rat digestive tract.
Biochim Biophys Acta. 1998 Mar 2;1379(3):325-36. PMID: 9545594 [PubMed - indexed for
MEDLINE]
Gamet-Payrastre
L, Lumeau S, Gasc N, Cassar G, Rollin P, Tulliez J.
Selective cytostatic and cytotoxic effects of glucosinolates hydrolysis products on human
colon cancer cells in vitro. Anticancer Drugs. 1998 Feb;9(2):141-8. PMID: 9510500 [PubMed
- indexed for MEDLINE]
Kassahun
K, Davis M, Hu P, Martin B, Baillie T.
Biotransformation of the naturally occurring isothiocyanate sulforaphane in the rat:
identification of phase I metabolites and glutathione conjugates. Chem Res Toxicol. 1997
Nov;10(11):1228-33. PMID: 9403174 [PubMed - indexed for MEDLINE]
Morel
F, Langouet S, Maheo K, Guillouzo A.
The use of primary hepatocyte cultures for the evaluation of chemoprotective agents. Cell
Biol Toxicol. 1997 Jul;13(4-5):323-9. Review. PMID: 9298252 [PubMed - indexed for MEDLINE]
Maheo
K, Morel F, Langouet S, Kramer H, Le Ferrec E, Ketterer B, Guillouzo A.
Inhibition of cytochromes P-450 and induction of glutathione S-transferases by
sulforaphane in primary human and rat hepatocytes. Cancer Res. 1997 Sep 1;57(17):3649-52.
PMID: 9288764 [PubMed - indexed for MEDLINE]
Paolini
M, Biagi GL, Cantelli-Forti G.
Re: Barcelo, S., Gardiner, J.M., and Gescher, A. and Chipman, J.K. (1996) CYP2E1-mediated
mechanism of anti-genotoxicity of the broccoli constituent sulforaphane. Carcinogenesis,
17, 277-282. Carcinogenesis. 1997 Jul;18(7):1435-6. No abstract available. PMID: 9230294
[PubMed - indexed for MEDLINE]
Barcelo
S, Gardiner JM, Gescher A, Chipman JK.
CYP2E1-mediated mechanism of anti-genotoxicity of the broccoli constituent sulforaphane.
Carcinogenesis. 1996 Feb;17(2):277-82. PMID: 8625450 [PubMed - indexed for MEDLINE]
Talalay
P, Fahey JW, Holtzclaw WD, Prestera T, Zhang Y.
Chemoprotection against cancer by phase 2 enzyme induction. Toxicol Lett. 1995
Dec;82-83:173-9. Review. PMID: 8597048 [PubMed - indexed for MEDLINE]
Zhang
Y, Kensler TW, Cho CG, Posner GH, Talalay P.
Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl
isothiocyanates. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):3147-50. PMID: 8159717
[PubMed - indexed for MEDLINE]
Zhang
Y, Talalay P, Cho CG, Posner GH.
A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and
elucidation of structure. Proc Natl Acad Sci U S A. 1992 Mar 15;89(6):2399-403. PMID:
1549603 [PubMed - indexed for MEDLINE]
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